Aim: This study aims to identify the challenges of pharmacy information systems (PIS) in Iran.
Method: The present study is a systematic literature review. Initially, sources were retrieved using a search strategy and via Persian sites such as SID, Iranmedex, and Magiran, and databases like Embase, WOS, PubMed, ProQuest, and Scopus. Then, the sources related to the research were selected and examined using inclusion, and exclusion criteria, and finally, the findings were classified in the form of the challenges of the PIS.
Results: 16 studies were entered into this research. The results of evaluations displayed that the challenges of PIS included four parts: 1) documentation challenges, 2) lack of support for clinical decisions 3) standard policies and rule-related challenges, 4) challenges regarding non-compliance of designed plans to the responsibilities of a pharmacy
Conclusion:  Due to the main goal of the pharmacy information system regarding the increase clients' satisfaction along with cost reduction, and developing a PIS, removing challenges and problems is necessary.