Shahid Sadoughi University of Medical Sciences Applied Health Information Technology 2717-3631 3 1 2022 07 25 Challenges of Pharmacy Information System in Iran: A Systematic Literature Review 39 46 283 10.18502/ahit.v3i1.10129 EN Journal Article 2021 12 03 <strong>Aim: </strong>This study aims to identify the challenges of pharmacy information systems (PIS) in Iran. <strong>Method: </strong>The present study is a systematic literature review. Initially, sources were retrieved using a search strategy and via Persian sites such as SID, Iranmedex, and Magiran, and databases like Embase, WOS, PubMed, ProQuest, and Scopus. Then, the sources related to the research were selected and examined using inclusion, and exclusion criteria, and finally, the findings were classified in the form of the challenges of the PIS. <strong>Results: </strong>16 studies were entered into this research. The results of evaluations displayed that the challenges of PIS included four parts: 1) documentation challenges, 2) lack of support for clinical decisions 3) standard policies and rule-related challenges, 4) challenges regarding non-compliance of designed plans to the responsibilities of a pharmacy <strong>Conclusion: </strong> Due to the main goal of the pharmacy information system regarding the increase clients' satisfaction along with cost reduction, and developing a PIS, removing challenges and problems is necessary.  https://ahit.ssu.ac.ir/article_283_9beb15f993fb697d81bfb80e3dc4c059.pdf